TRPV4 agonist

TRPV4 agonist - Names and Identifiers

Name	4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-, hydrochloride (1:1)
Synonyms	OUN67600 TRPV4 agonist RPV4 agonist-1 TRPV4 agonist-1 OUN67600(TRPV4 agonist-1)
CAS	2314467-60-0

TRPV4 agonist - Physico-chemical Properties

Molecular Formula	C25H23ClF2N4O2
Molar Mass	484.93
Solubility	Soluble in DMSO
Storage Condition	-20℃
Use	OUN67600, is a Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonist as Regulators of Chondrogenic Differentiation.

TRPV4 agonist - Reference

Reference

Atobe M, Nagami T, Muramatsu S, Ohno T, Kitagawa M, Suzuki H, Ishiguro M, Watanabe A, Kawanishi M. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Feb 14;62(3):1468-1483. doi: 10.1021/acs.jmedchem.8b01615. Epub 2019 Jan 28. PMID: 30629441.